$87 Find Cheap Flights from St. Louis to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to South Carolina departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to South Carolina, as well as popular online travel agencies
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Best South Carolina Flight Deals from St. Louis

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Charleston
Charleston1 stop$291
Myrtle Beach
Myrtle Beach1 stop$248
Greenville
Greenville1 stop$272
Columbia
Columbia1 stop$224

Cheap Flights from St. Louis to South Carolina

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.

Recent round-trip flight deals from St. Louis to South Carolina

Recommended round-trip deals departing in the coming months from the most popular airlines that fly from St. Louis to South Carolina.
Discover the best prices for you by selecting your travel dates on KAYAK.
Choose your dates
Frontier Logo
5:45 pm - 5:56 pmSTL-CLT
23h 11m1 stop
Frontier Logo
10:36 pm - 12:14 amCLT-STL
26h 38m1 stop
$181Frontier
Find Deal
Wed, May 7 - Thu, May 8
Frontier Logo
5:55 pm - 5:52 pmSTL-CLT
22h 57m1 stop
Frontier Logo
10:36 pm - 12:06 amCLT-STL
26h 30m1 stop
$191Frontier
Find Deal
Fri, May 16 - Sun, May 18
American Airlines Logo
6:47 pm - 11:54 pmSTL-CAE
4h 07m1 stop
American Airlines Logo
6:10 am - 10:43 amCAE-STL
5h 33m1 stop
$224American Airlines
Find Deal
Sat, May 24 - Mon, May 26
Spirit Airlines Logo
10:10 am - 9:05 pmSTL-MYR
9h 55m1 stop
Spirit Airlines Logo
6:10 am - 10:33 amMYR-STL
5h 23m1 stop
$248Spirit Airlines
Find Deal
Sun, Jun 8 - Fri, Jun 13
American Airlines Logo
6:04 am - 3:20 pmSTL-CAE
8h 16m1 stop
American Airlines Logo
8:43 pm - 11:59 pmCAE-STL
4h 16m1 stop
$249American Airlines
Find Deal
Thu, Jun 26 - Mon, Jun 30
Delta Logo
10:05 am - 3:20 pmSTL-HHH
4h 15m1 stop
Delta Logo
12:00 pm - 4:18 pmHHH-STL
5h 18m1 stop
$249Delta
Find Deal
Tue, Jun 3 - Tue, Jun 10
Delta Logo
3:40 pm - 10:56 pmSTL-CAE
6h 16m1 stop
Delta Logo
6:05 am - 11:48 amCAE-STL
6h 43m1 stop
$254Delta
Find Deal
Wed, May 7 - Tue, May 13
Southwest Logo
10:30 am - 1:20 pmSTL-CLT
1h 50mnonstop
Southwest Logo
4:20 pm - 5:25 pmCLT-STL
2h 05mnonstop
$290Southwest
Find Deal
Tue, May 27 - Fri, May 30
Spirit Airlines Logo
10:10 am - 12:50 pmSTL-MYR
25h 40m2 stops
Spirit Airlines Logo
6:10 am - 10:33 amMYR-STL
5h 23m1 stop
$291Spirit Airlines
Find Deal
Sun, Jun 8 - Fri, Jun 13
Southwest Logo
12:25 pm - 5:15 pmSTL-MYR
3h 50m1 stop
Southwest Logo
10:15 am - 2:10 pmMYR-STL
4h 55m1 stop
$293Southwest
Find Deal
Tue, May 20 - Sat, May 24

KAYAK's insights & trends for St. Louis to South Carolina flights

Get data-powered insights and trends into flights from St. Louis to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest St. Louis to South Carolina flight route?

The cheapest price for flight routes found by users searching on KAYAK in the last 2 weeks for round-trip flights from St. Louis to South Carolina.
The cheapest ticket to South Carolina from St. Louis found in the last 72 hours was to Charleston, at $271 round-trip. The most popular route is from St. Louis (STL) to Charleston (CHS), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $271.

What is the cheapest time of day to fly to South Carolina?

The average price for all round-trip flights from St. Louis to South Carolina depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.
The cheapest time of day to fly to South Carolina is generally in the afternoon, when round-trip flights cost $373 on average. The most expensive time of day to fly to South Carolina is generally in the morning, which is peak travel time and where the average cost of a ticket is $439.

Can I save money by flying with a layover from St. Louis to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.
No, with an average price for the route of $235, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from St. Louis to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.
The cheapest month for flights from St. Louis to South Carolina is July, when tickets cost $304 (return) on average. On the other hand, the most expensive months are March and December, when the average cost of round-trip tickets is $433 and $409 respectively.

What’s the cheapest day of the week to fly from St. Louis to South Carolina?

The average price of all round-trip flights from St. Louis to South Carolina clicked on KAYAK for each day over the last 12 months.
If you are looking for a flight deal from St. Louis to South Carolina, look for departures on Tuesdays and avoid leaving on a Thursday, as it's usually the priciest day. When flying back from South Carolina, Thursday is the cheapest day to fly and Saturday is the most expensive.

How far in advance should I book a flight from St. Louis to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.
To get a below average price on the flight from St. Louis to South Carolina, you should book around 3 weeks before departure. For the absolute cheapest price, our data suggests you should book 10 weeks before departure.

Good to know

Low season

January

High season

May

Cheapest flight

$87
Best time to beat the crowds with an average 7% drop in price.
Most popular time to fly and prices are also 2% lower on average.
Flight from St. Louis to Myrtle Beach

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from St. Louis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from St. Louis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from St. Louis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from St. Louis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from St. Louis to the following destinations at these prices or less: Charlotte $174 one-way - $352 round-trip

Top 5 airlines serving from St. Louis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4287 reviews
7.6Entertainment
7.1Food
8.2Boarding
8.0Comfort
8.6Crew
Airline reviews

I’ve always loved Southwest. No issues at all. I was flying standby and the gate agent was extremely friendly and helpful. Boarding was smooth and I was able to get a window seat in the emergency exit row. Crew was fantastic! They were very professional and accommodating. We had to divert from our destination due to weather but the flight crew kept everyone at ease and informed us of all pertinent information. Excellent flight

8.0 ExcellentJonathan, Apr 2025AUS - MSY
Read more Southwest reviews

I’ve always loved Southwest. No issues at all. I was flying standby and the gate agent was extremely friendly and helpful. Boarding was smooth and I was able to get a window seat in the emergency exit row. Crew was fantastic! They were very professional and accommodating. We had to divert from our destination due to weather but the flight crew kept everyone at ease and informed us of all pertinent information. Excellent flight

The price of the tickets isn't matching the flight experience. No matter how long the flight is, you're only getting pretzels. The flight attendants looked unkept and over it.

Plz don't take away free bags and free seating

The seats were a bit cramped and worn, but otherwise okay.

I would have liked to arrive on time - not 5 hours late!

After a 3 hour layover in Denver my flight was delayed over 5 hours! No explanation; no assistance; no offer to provide compensation; no one at Southwest was willing to offer any assistance. 8 hours in the Denver airport - ridiculous!

It was a perfect flight in all aspects! Both legs!

Only one drink pass through the cabin for a 4 hour flight. Quite rough and bumpy landing.

Boarding process, crew were good. But the seats were so uncomfortable that was all I could focus on. I literally had to sit forward so that all 3 of us could fit in row. I will try to avoid Southwest in the future for any flights over 60 minutes.

1.5 hour delay, poor service, no compassion from the crew. Terrible experience

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

Delayed take-off. Very small plane so very scary with lots of bumps during the flight. Would never fly Delta on short flights in small 80 seaters plane again! Felt relieved when landed.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

A little bumpy ride . No food was being provided due the the turbulence. That was ok it was a short flight to my standards.

Simply outstanding. Their new lounge for Delta One customers is a cut above the rest.

The Dekta Rep that checked us in was great. She's very personable, pleasant, and can tell she enjoys her job.

The plane was old with small storage areas that had problems closing/latching and not enough storage for everyone, and worn, damaged seats. Service was great but feel a little unsafe on such well used planes.

Terrible and im avoiding them in the future. My initial flight was delayed causing me to rebook my flight and when speaking with the representative to rebook I explained this is the second time my flights were delayed and they did nothing to help me. I wasn't booked to comfort plus or given a voucher or anything. I was almost late for my meeting that I needed to attend on Monday because of the games delta played delaying my flights even more and putting me in the very back of the plane next to an extremely intoxicated passenger

Flights on time. .Ride was as comfortable as can be expected in steerage. Luggage arrived at destination. Attendants were fairly friendly.

Great staff. Wifi is terrible. Signing up for skylines is a painstaking process. Had to call customer service just to get my flight itinerary and confirmation sent to me. Consistent delays. A well staffed company that is run so poorly. Upper management needs to be renewed.

Multiple delays and not straight answer from the United team

Stewardess spilled orange juice on my clothes/seat no help no apology just threw napkins at me to clean the mess up. Not Happy.

Smooth flight. Boarding was chaotic. Could not hear the gate agent over the intercom. People were lined up in the wrong lines. Groups one and two were told to board through line one and group 3 through line 2. All very confusing. Once in the air, the flight was smooth. There was no entertainment option on this aircraft, even though it was a larger aircraft.

The plane pushed back from the gate on time. However, it stopped on the ramp, and we waited for over 20 minutes before the aircraft pulled back to the gate. Apparently, something of importance had to be removed from the aircraft by the gate agent. I found this to be odd. The delay was not significant, but I felt that whatever was on the aircraft that had to be taken off, should’ve been done before we pushed back from the gate.

Electric plugs didn't work. Entertainment system wasn't working

The design of the light switch on the arm rest is ridiculous.

Smooth boarding process. Early departure, smooth flight, early arrival. The entertainment package has very good recent movie options. The flight crew were friendly and professional.

leg space better than expected. two washrooms for one plane isn't enough.

The gate attendant let me walk right by her with a bag too big for the overhead compartment

I just got back from a trip with 3 flights each way. The flights were good and we were happy with out experience. There was one steward on our first flight that was harsh and grump with passengers. It did not leave a good impression. All of the other flight crews were great on the other five flights.

We missed our flight. The boarding pass had the wrong gate and by the time we received the text from Kayak, our flight was already gone. I’ll never use Kayak again and will go direct to the airlines in the future.

Boarding took forever, the plane was cramped and cold, and the seatbelt song came on constantly throughout the red eye flight with a loud pre-recorded message playing each time

Cabin felt crammed Snacks are lame But crew was super efficient getting us out on time despite delay

Took off on time and successfully avoided weather that looked to be a problem along the way

There were five broken seats on the plane. The crew was very rude in telling people they had to get off the plane and get a flight the next day. No call for volunteers, but telling people they had to get off. One woman was flying with her elderly mother and daughter and was told she had to leave or all three had to leave. Fortunately, a volunteer offered to stay. The situation was handled poorly.

The flight to Tokyo AA61 took off about two hours late, but then had to turn back. By that time the crew had to be replaced. Then they kept promising to take off in an hour, then in 3, then switch to the next day.

Any sort of gluten free snack option would be nice

They lost my luggage and it didn’t get delivered until the next day.

Would have thought that they would gas up plane before everyone got on board

3 hours late. Not even water offered on a 2.25 hour flight.

terrible service, no room for a dog underfoot, a broken chair that is impossible to sit on and all this costs a lot of money

Easy boarding. Met expectations for a 2-3 hour flight. Early arrival at DFW caused a 39 minute delay on the tarmac in getting to our gate. 😏 overall, good flight.

Very efficient process and boarding, seats felt standard. Flight conditions from take off to landing had been very smooth. Alcohol on the menu however was not available… Will fly Spirit in the future for the price, you can’t really complain if you fly light.

It’s what we expected from Spirit..reasonable cost, good for a 2-3 hour flight. Disappointed that we had a 2 hour delay in departure from DFW for a maintenance issue, but the pilot handled it well once we were outbound on a different Airbus.

Worst airline ever! The guy weighing my bag had his foot on the metal plate and when I called him out on it, I got this stupid little smirk. La is a scam and so is Spirit Airlines. All the flight attendants looked like they hated our flight just as much as we did.

My experience with Spirit went pretty much as expected. It's a no frills airline, and you get what you pay for. I don't require much, so I was grateful to have an inexpensive way to travel. It is sad to me that the gate agents and flight crew don't smile much or seem very friendly or helpful. They are competent and efficient, and that's really all I need.

My experience was okay. The flight did not offer even water without a fee. Also had to pay extra for my carry on, as I was told I had to check my bag, even though it said I had the option to carry on a bag when booking. This costed me an extra $100. Would likely not fly with Spirit again.

The flight was rescheduled several times without a reason for the schedule changes. I had to be in New Orleans at a certain time and it was just easier to drive at a certain point. I don’t know if the flight ever left. This is my first experience with Spirit Airlines and is also the last.

It was fast but uncomfortable seats. Had to pay a bit extra not sure why? Maybe in selection of all my 4 tix together ? Just knew I had a balance before getting boarding pass online when departing from satx ? And flight was delayed..

In a word, it was horrible. The flight crew timed out and this, apparently was not accounted for by management. This meant that our 10:15 departure turned into a 1:30am departure the next DAY!!! And some brainchild decided to email us 12$ food vouchers set to expire the 9th, but they sent them after EVERY VENDOR WAS CLOSED in the Miami airport and obviously none would be open in New Orleans. I found this to be another sterling example of, at best, shitty management…at worst an absolute lack of empathy for your customers. Triplt Pro: Check-in may be avail for NK222 dep MIA 4/8/2025 10:16pm. Conf#RGSUMI. https://tripit.com/t/. e106fd644e0a; Today 6:16 PM TripIt Pro: NK222 ON TIME. MIA dep 10:16pm term C, gate F5. MSY arr 11:38pm. Today 8:59 PM Tript Pro: NK222 DELAYED. MIA dep 1:00am term C, gate F5. MSY arr 2:18am. Alternate flights: https:// www.tripit.com/t/b2903869f438 Triplt Pro: NK222 PULLED IN. MIA dep 12:30am term C, gate F5. MSY arr 1:48am. Alternate flights: https:/// www.tripit.com/t/834d176c630b Tript Pro: NK222 DELAYED. MIA dep 1:00am term C, gate F5. MSY arr 1:48am. Alternate flights: https:/// www.tripit.com/t/0441e41a9dd3 Triplt Pro: NK222 PULLED IN. MIA dep 12:30am term C, gate F5. MSY arr 1:48am. Alternate flights: https:// www.tripit.com/t/92ac2157ef54 The sender is not in your contact

Everything you need to know for your flight from St. Louis to South Carolina

Information on your arrival and departure airports

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