$60 Find Cheap Flights from St. Louis to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to South Carolina departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to South Carolina, as well as popular online travel agencies
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Best South Carolina Flight Deals from St. Louis

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Charleston
Charleston1 stop$161
Myrtle Beach
Myrtle Beach1 stop$237
Greenville
Greenville1 stop$287
Columbia
Columbia1 stop$224
Florence
Florence1 stop$368

Good to know

Low season

January

High season

June

Cheapest flight

$60
Best time to beat the crowds with an average 10% drop in price.
Most popular time to fly with an average 4% increase in price.
Flight from St. Louis to Charlotte

FAQs - booking South Carolina flights

  • How long is the flight to South Carolina from St. Louis?

    Flights to Myrtle Beach2h 02m
    Flights to Charleston0h 00m
  • What is the cheapest flight to South Carolina from St. Louis?

    The cheapest ticket to South Carolina from St. Louis found in the last 72 hours was $60 one-way, and $123 round-trip. The most popular route is from St. Louis to Charleston, and the cheapest round-trip airline ticket found on this route in the last 72 hours was $81.

  • How does KAYAK find such low prices on flights from St. Louis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from St. Louis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from St. Louis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from St. Louis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from St. Louis to the following destinations at these prices or less: Charlotte $191 one-way - $374 round-trip
  • Book at least 1 week before departure in order to get a below-average price.
  • High season is considered to be March, April and May. The cheapest month to fly from St. Louis is February.
  • Morning departure is around 6% cheaper than an evening flight, on average*.
See more tips
*Average of the lowest prices shown in KAYAK’s search results for departures within the next 30 days

Top 5 airlines serving from St. Louis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.1
SouthwestOverall score based on 4659 reviews
8.2Boarding
7.2Food
8.1Comfort
8.7Crew
7.7Entertainment
Airline reviews

Flight was awfully bumpy and landing was a bit jolting. I was in the restroom when snacks and drinks were served and was not asked if i wanted any. I had to ask for water finally.

10.0 ExcellentRachel, Jan 2025TPA - MDW
Read more Southwest reviews

Flight was awfully bumpy and landing was a bit jolting. I was in the restroom when snacks and drinks were served and was not asked if i wanted any. I had to ask for water finally.

Wi Fi was horrible kept cutting out the whole time and too expensive

I really like open seating. I hate that I've heard this is going away. This is one of the unique things that makes Southwest my goto choice.

Boarding was a little late, but made up for it. It was quick to taxi to the runway, since it's a smallish airport.

Excellent! Only question is how we check in at exactly 24 hours in advance and end up at the end of the B boarding group

Multiple delays and gate changes. Arrived at final destination 6 hours late. All rental cars had been taken.

Employees were kind and funny, as always! Flight was late but no announcements were made for people with tight connections to help them transition quickly. No service due to turbulence.

It was 2 hours 45 minutes late, for no apparently clear reason.

I recently flew Southwest from San Jose to Honolulu. I was very impressed with the flight crew, especially the flight attendant in charge of the front of the plane. She came through the aisle at least five times for drinks and water, and two times for snacks. I have not seen such service since I flew first class. Also, for the first time, they gave us the correct baggage claim number, and the luggage came out quickly. I can't wait for Southwest to have assigned seating! I absolutely hate the Cattle Call boarding procedure and the mad dash to get seats and overhead bins. However, the boarding was efficient.

Crew was great flight was great baggage claim was a failure. It took over 1 hour for bags to arrive. Poor communication poor effort when I spoke to the supervisor about the delay

Great service. Great staff. Boarding was a little slow, but I think there was a service dog slowing things down.

Flight left early and arrived early. the whole trip was excellent.

Seats were really tight and the seat belts did not give enough slack.

I like in St George and prefer to fly out of CDC than SGU. Hopefully, they will continue the flights out of Cedar

Broken jer bridge. Poor communication about it. Lost 2 of 4 luggage pieces

Overall, it was okay. Seat was a little cramped. Would’ve liked more substantial snacks or opportunity to buy some.

Newer plane, relatively easy boarding, not a full flight and was told that we could not be moved up because of weight and balance issues. Otherwise, a very good experience.

Other then mechanical/ computer problem and 3.5 hours flight delay the flight was great. I guess that what happened when you fly an old airplane now a day.

I was with one of the last zones to board. It was kind of annoying to finally get called to board and my whole section was already on the plane. Clearly they boarded with previous zones. So by the time I got on board, there were no spaces for my luggage above my head. I had to put my luggage 4+ rows behind me, which meant that I had to wait even longer to get off the plane, since I had to wait for those rows to clear the aisle before I could retrieve my luggage and exit the plane. This also held up the plane cleaners, as they couldn't service my row until I cleared it, so they were all standing there waiting for me, while I'm standing there waiting for the other passengers to clear the aisle. Anyways, I wasn't in a rush this time, so I just waited, but I could see that being a problem in the future. Now, I could have checked my luggage, of course, but coincidentally, a friend of mine on the same flight got their luggage damaged (wheel completely knocked off) and was told by the Baggage Attendant in the airport that Delta doesn't "cover wheel damage" on luggage. This was disappointing to hear. I'm glad I didn't check mine through. If it were my luggage, I'd be highly frustrated to hear that. It makes me not want to check my luggage in the future.

The dear was very limited in space. I could put my water bottle in seat basket. Also, there was no inflight entertainment in the delta app?

I liked all the informational texts. I always knew where to go and when .

Liked the hospitality . The ight took us 6 hrs to get from fort myers to ewr.

Oh my gosh, I loved my experience with United! they made me want to travel more often.

The flight attendants in First Class were mediocre at best. They did not take our tray away until we were about to land and only did so when I press the call button. The United person at the United Club was asked to get us our boarding pass since we missed the flight due in Chicago. She argued that we did not have seats on the flight given to us in Moline. Furthermore, she was adamant that we did not have a First Class ticket. After I spent much time with her trying to show we were correct, she reluctantly agreed. She was probably the most incompetent ticketing person I have ever met and I have traveled 3 million miles on United plus many additional miles with other carriers. United has definitely deteriorated in more than on way.

The plane was in Moline all night. Consequently, we assumed an on time departure at 8:15am. Unfortunately, and as is the normal case with United in Moline, we departed 2.5 hours late. When the crew came, it was discovered that there was very little heat in the plane. Seems this should have been checked hours before the crew arrived. Then when we boarded and the plane was to be de-iced, the United de-icing truck was not working! We awaited the American Airlines truck. All of this caused us to miss our connection in Chicago. My suggestion is never take United Airlines flight from Moline. We have been disappointed 80% of the time and have vowed to not take United again from Moline.

Flight was delayed two hours. No snacks and no tv screens. My bag got stuck in Chicago

Awful. Worst airline I have ever been on. Crew were among the rudest people I have ever dealt with. United staff members were rude and disrespectful. My flight was delayed, causing me to miss a connecting flight. I understand things happen, but when staff start lying about what actually happened, that is when I have an issue. Just be honest, really it isn’t that hard. I’m being very honest with this review and I don’t find this difficult what so ever. In fact, because of United Airlines, my Christmas holiday was off to a really rocky start. As someone who has traveled across the world, it has only been United that I have had a truly awful experience.

Received an email the night before showing that there would be seatback entertainment on our flight. We get on and there was no seatback entertainment. And then it was a scramble to try to set up the iPads for the kids before takeoff so they could watch something for the four hour flight.

The aircrew was solid, the flight was chill, I had no issues. The gate agent was not the best. I was trying to use a military bag upgrade to move my bag from under the seat to the overhead bins and he told me there’s no overhead bins on the plane, argued with me why booking put a military member in basic economy (I don’t really understand this) and made it an issue to even try to help me stating I’d have to call reservations to get a bag upgrade. When every other agent with United can add it at the gate, this man couldn’t be bothered.

Short flight - no food understandable. Flight was delayed for over an hour. Overall, it was good.

Small plane, so no entertainment. Hour delay! Nobody explained wht the delay was all about.

I wasn’t happy with the hour delay from Dallas to McAllen, but that is the nature of travel. I don’t like to fly in general because of all of the problems all the time.

It went up and down at the right time and place. I’m happy with that outcome.

Staff at the gate were incredibly rude, hostile and threatening. Never fly American Airlines.

Would have been good to have a meal since it was a 5.5 hour flight

Same problems with delays in Dallas. This was weather related and due to the incoming flight being delayed. This was the flight that was delayed due to a missing flashlight which turned out not to be missing.

Most of the delay was due to weather which is not what was at issue here. One delay was due to a missing flashlight and in the end the flashlight was actually found on the plane. The entertainment system is very limited. Live TV options offer only a few channels that are not very appealing. Boarding and deplaning are always difficult. It just takes too much time to get on and off the plane. On the plus side, I missed my connecting flight, but was easily able to book a later flight from the app while enroute.

I had a horrible experience from the time I dropped off my bags until the time I landed. The staff taking the bags at the check-in counter prior to security, forced me to check my baby stroller, even though it weighed less than 20 pounds. their excuse was that the wheels were too big. I have never had an issue gate checking this exact same stroller in the past either on American or on any other airline. when I asked for the agent to show me the rule about the size of the wheels on strollers, they told me to look it up on the AA website. I did so, and did not find any indication that wheel size was a problem for gate checking strollers. The only limitation would be the weight of the stroller which mine was below. I was left with a one-year-old child and all of my carry-on luggage, diaper bag, and the like to walk around the airport without the assistance of a stroller and had the same issue when I exited the plane and had to go all the way to baggage claim without a stroller. In addition, while on the airplane, I was told I can only get one bag of cookies as a snack, even though I was with a child. Apparently my child and I were supposed to share a cookie. While this latter issue is a minor one, it is just another example of the absolutely horrible customer service that American Airlines provides. In addition, the 737 aircraft that I was on was extremely hot and the air vents above the seat were so far away from the aisle and middle seats that it was comical. I could barely reach the air vent to adjust it. I had to ask the person in the window seat to do it for me. The whole experience was just a nightmare.

We boarded after several delays due to mechanical failure and a gate change. The seat cushion in the exit row was very compressed and offered no cushion, making the four-hour journey reasonably uncomfortable. The WiFi worked for a few people, but for most, it did not, and you cannot get entertainment unless you can connect—American Airlines flights do not have seatback screens, and you must use your mobile phone.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

From gate to flight crew... All Spirit employees were great! Everyone was kind and helpful. Ride was almost smooth... A few bumps... But no problems. Seats were tight and uncomfortable. Our biggest issue was no free drinks. I can understand paying for adult beverages and can understand no snacks on a 3 hour flight... But no drinks???? I had to pay $4 for an apple juice for my son. That's not right. You should probably reconsider that.

- flight attendants not very friendly. - Paid for WiFi and plane didn’t have it working , never got a refund.

Great! First time flying with Spirit and I definitely loved it!

Not efficient. Missed my connecting flight over improper operation of spirit crew.

Very difficult. Flew out on Dec 24th and it was a mess. They know it is going to be the busiest time of the year and they had no organization. Finally they called for people going on certiam flights so they could get them thru thw line then we had to rush to our gate to get in li e to board.We missed our flight do to being stuck at the border of Mexico. They would not work with us to make an affordable price so we had to wait a day with no where to go and pay 280 more for our flights. I would think that a complimentary drink would be nice. But we had to pay 4.49 for a coke. Not an overall good experience

Better service, stop treating people like cattle, have REAL FOOD for the price of the ticket. YOU ARE IN BANKRUPTCY, WAKE UP!!! ... DO BETTER, PLAN BETTER, GIVE COMFORT AND CARE TO PASSENGERS ... EARN RESPECT AND ADMIRATION, YOU'LL BE REWARDED BY THE PUBLIC.

It was good. All snacks/ drinks must be paid during flight. Bring cash with you.

The plane had to wait an hour before docking, then another 1.5 hrs to get our luggage. Bad experience.

The ticket agent wouldn't check our bags, eventhough the flight was delayed and wouldn't board for another hour. The gate agents were only mildly better than the ticket agent. They also had a terrible attitude and work ethics.

The check-in process at Spirit was horrible. There was no one directing the hundreds of people trying to check-in and drop bags at Spirit. We got in multiple lines and were later told it wasn’t a line. The check-in process needs to be improved. The flight and crew were great.

Book cheap flights from St. Louis to South Carolina

Recent round-trip flight deals

 
These are the cheapest round-trip flights from St. Louis to South Carolina found on KAYAK in the last 72 hours.
2/18Tue
1 stopSpirit Airlines
6h 41mSTL-CLT
2/25Tue
1 stopSpirit Airlines
9h 02mCLT-STL
$123
2/1Sat
1 stopFrontier
22h 06mSTL-CLT
2/8Sat
1 stopFrontier
13h 46mCLT-STL
$140
2/16Sun
1 stopAmerican Airlines
4h 31mSTL-CAE
2/22Sat
1 stopAmerican Airlines
4h 53mCAE-STL
$224
2/5Wed
1 stopAmerican Airlines
6h 46mSTL-CAE
2/9Sun
1 stopAmerican Airlines
5h 48mCAE-STL
$249
2/6Thu
nonstopSouthwest
1h 45mSTL-CLT
2/9Sun
nonstopSouthwest
2h 10mCLT-STL
$275
2/6Thu
nonstopSouthwest
1h 45mSTL-CLT
2/9Sun
1 stopSouthwest
6h 55mCLT-STL
$285
2/4Tue
1 stopDelta
5h 49mSTL-GSP
2/11Tue
1 stopDelta
5h 24mGSP-STL
$287
3/1Sat
1 stopDelta
6h 33mSTL-GSP
3/8Sat
1 stopDelta
4h 40mGSP-STL
$297
2/12Wed
2 stopsUnited Airlines
8h 14mSTL-CLT
2/15Sat
1 stopUnited Airlines
5h 16mCLT-STL
$314
3/26Wed
2 stopsUnited Airlines
6h 46mSTL-GSP
3/29Sat
1 stopUnited Airlines
6h 42mGSP-STL
$322

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Recent one-way flight deals

 
Only flying one-way? Below are some of the best one-way flight deals from St. Louis to South Carolina found on KAYAK in the last 72 hours.
2/18Tue
1 stopSpirit Airlines
6h 41mSTL-CLT
$60
2/18Tue
1 stopSpirit Airlines
6h 41mSTL-CLT
$62
2/15Sat
1 stopAmerican Airlines
8h 55mSTL-CLT
$137
2/12Wed
1 stopDelta
4h 06mSTL-CLT
$148
2/15Sat
nonstopAmerican Airlines
2h 00mSTL-CLT
$153
2/12Wed
1 stopDelta
3h 45mSTL-CHS
$162
2/15Sat
2 stopsSouthwest
11h 45mSTL-CLT
$167
2/15Sat
2 stopsUnited Airlines
10h 16mSTL-CLT
$168
2/16Sun
nonstopSouthwest
1h 45mSTL-CLT
$177
2/12Wed
2 stopsUnited Airlines
8h 35mSTL-CLT
$188

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Last minute flights from St. Louis to South Carolina

Last minute flight, train and bus deals

 
These last-minute flight deals are the cheapest flights found on KAYAK in the last 72 hours for flights from St. Louis to South Carolina that are departing in the next 10 days.
1/18Sat
multi-stopFrontier
13h 50mSTL-CLT
1/25Sat
multi-stopFrontier
6h 00mCLT-STL
$268
1/19Sun
multi-stopSpirit Airlines
5h 30mSTL-CHS
1/21Tue
multi-stopSpirit Airlines
8h 28mCHS-STL
$321
1/19Sun
multi-stopAmerican Airlines
6h 00mSTL-HHH
1/25Sat
multi-stopAmerican Airlines
6h 41mHHH-STL
$334
1/19Sun
multi-stopAmerican Airlines
9h 15mSTL-HHH
1/25Sat
multi-stopAmerican Airlines
6h 41mHHH-STL
$339
1/21Tue
multi-stopDelta
10h 50mSTL-GSP
1/28Tue
multi-stopDelta
16h 06mGSP-STL
$533
1/21Tue
multi-stopDelta
10h 50mSTL-GSP
1/27Mon
multi-stopDelta
11h 53mGSP-STL
$576
1/20Mon
multi-stopUnited Airlines
6h 30mSTL-CHS
1/27Mon
multi-stopUnited Airlines
9h 38mCHS-STL
$710
1/20Mon
multi-stopUnited Airlines
13h 02mSTL-CHS
1/27Mon
multi-stopUnited Airlines
9h 47mCHS-STL
$715
1/17Fri
multi-stopSouthwest
8h 20mSTL-SAV
1/20Mon
multi-stopSouthwest
8h 30mSAV-STL
$846
1/17Fri
multi-stopSouthwest
6h 30mSTL-CLT
1/20Mon
multi-stopSouthwest
9h 20mCLT-STL
$848

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Everything you need to know for your flight from St. Louis to South Carolina

Information on your arrival and departure airports

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