$55 Find Cheap Flights from Indianapolis to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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These are the airlines KAYAK users have selected most often from within our search results in flight searches from Indianapolis to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Indianapolis to South Carolina, as well as popular online travel agencies
In the last 7 days travelers have searched 41,299,237 times on KAYAK, and here is why:

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Best South Carolina Flight Deals from Indianapolis

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Charleston
Charlestonnonstop$170
Myrtle Beach
Myrtle Beach1 stop$155
Greenville
Greenville1 stop$263
Columbia
Columbia1 stop$229

Good to know

Low season

January

High season

June

Cheapest flight

$55
Best time to beat the crowds but there is an average 1% increase in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from Indianapolis to Charlotte

FAQs - booking South Carolina flights

  • How long is the flight to South Carolina from Indianapolis?

    Flights to Myrtle Beach0h 00m
  • What is the cheapest flight to South Carolina from Indianapolis?

    The cheapest ticket to South Carolina from Indianapolis found in the last 72 hours was $55 one-way, and $124 round-trip. The most popular route is from Indianapolis to Myrtle Beach, and the cheapest round-trip airline ticket found on this route in the last 72 hours was $69.

  • How does KAYAK find such low prices on flights from Indianapolis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Indianapolis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Indianapolis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Indianapolis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Indianapolis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Indianapolis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Indianapolis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Indianapolis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Indianapolis to the following destinations at these prices or less: Charlotte $169 one-way - $358 round-trip
  • Book at least 1 week before departure in order to get a below-average price.
  • High season is considered to be January, February and March. The cheapest month to fly from Indianapolis is January.
  • On average*, there is no price difference when choosing to fly in the morning or the evening on this flight route.
See more tips
*Average of the lowest prices shown in KAYAK’s search results for departures within the next 30 days

Top 5 airlines serving from Indianapolis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Indianapolis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Indianapolis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 8501 reviews
7.9Entertainment
8.0Comfort
8.2Boarding
7.3Food
8.6Crew
Airline reviews

Seats were really tight and the seat belts did not give enough slack.

8.0 ExcellentElizabeth, Jan 2025LGA - RIC
Read more Delta reviews

Seats were really tight and the seat belts did not give enough slack.

I like in St George and prefer to fly out of CDC than SGU. Hopefully, they will continue the flights out of Cedar

Broken jer bridge. Poor communication about it. Lost 2 of 4 luggage pieces

Overall, it was okay. Seat was a little cramped. Would’ve liked more substantial snacks or opportunity to buy some.

Newer plane, relatively easy boarding, not a full flight and was told that we could not be moved up because of weight and balance issues. Otherwise, a very good experience.

Other then mechanical/ computer problem and 3.5 hours flight delay the flight was great. I guess that what happened when you fly an old airplane now a day.

I was with one of the last zones to board. It was kind of annoying to finally get called to board and my whole section was already on the plane. Clearly they boarded with previous zones. So by the time I got on board, there were no spaces for my luggage above my head. I had to put my luggage 4+ rows behind me, which meant that I had to wait even longer to get off the plane, since I had to wait for those rows to clear the aisle before I could retrieve my luggage and exit the plane. This also held up the plane cleaners, as they couldn't service my row until I cleared it, so they were all standing there waiting for me, while I'm standing there waiting for the other passengers to clear the aisle. Anyways, I wasn't in a rush this time, so I just waited, but I could see that being a problem in the future. Now, I could have checked my luggage, of course, but coincidentally, a friend of mine on the same flight got their luggage damaged (wheel completely knocked off) and was told by the Baggage Attendant in the airport that Delta doesn't "cover wheel damage" on luggage. This was disappointing to hear. I'm glad I didn't check mine through. If it were my luggage, I'd be highly frustrated to hear that. It makes me not want to check my luggage in the future.

The dear was very limited in space. I could put my water bottle in seat basket. Also, there was no inflight entertainment in the delta app?

Typically I give delta excellent reviews. Our flight was delayed 2hrs, I was one of the fortunate ones who were able to get to my connecting flight. Also, annoying that on the connecting flight boarding personnel make me put away a small bag into my carryon. It small enough to put in back pocket seat, why hold me and the line up to just push it into my carryon.

Everything was great. Great service, excellent communication, and early arrival

Oh my gosh, I loved my experience with United! they made me want to travel more often.

The flight attendants in First Class were mediocre at best. They did not take our tray away until we were about to land and only did so when I press the call button. The United person at the United Club was asked to get us our boarding pass since we missed the flight due in Chicago. She argued that we did not have seats on the flight given to us in Moline. Furthermore, she was adamant that we did not have a First Class ticket. After I spent much time with her trying to show we were correct, she reluctantly agreed. She was probably the most incompetent ticketing person I have ever met and I have traveled 3 million miles on United plus many additional miles with other carriers. United has definitely deteriorated in more than on way.

The plane was in Moline all night. Consequently, we assumed an on time departure at 8:15am. Unfortunately, and as is the normal case with United in Moline, we departed 2.5 hours late. When the crew came, it was discovered that there was very little heat in the plane. Seems this should have been checked hours before the crew arrived. Then when we boarded and the plane was to be de-iced, the United de-icing truck was not working! We awaited the American Airlines truck. All of this caused us to miss our connection in Chicago. My suggestion is never take United Airlines flight from Moline. We have been disappointed 80% of the time and have vowed to not take United again from Moline.

Flight was delayed two hours. No snacks and no tv screens. My bag got stuck in Chicago

Awful. Worst airline I have ever been on. Crew were among the rudest people I have ever dealt with. United staff members were rude and disrespectful. My flight was delayed, causing me to miss a connecting flight. I understand things happen, but when staff start lying about what actually happened, that is when I have an issue. Just be honest, really it isn’t that hard. I’m being very honest with this review and I don’t find this difficult what so ever. In fact, because of United Airlines, my Christmas holiday was off to a really rocky start. As someone who has traveled across the world, it has only been United that I have had a truly awful experience.

Received an email the night before showing that there would be seatback entertainment on our flight. We get on and there was no seatback entertainment. And then it was a scramble to try to set up the iPads for the kids before takeoff so they could watch something for the four hour flight.

The aircrew was solid, the flight was chill, I had no issues. The gate agent was not the best. I was trying to use a military bag upgrade to move my bag from under the seat to the overhead bins and he told me there’s no overhead bins on the plane, argued with me why booking put a military member in basic economy (I don’t really understand this) and made it an issue to even try to help me stating I’d have to call reservations to get a bag upgrade. When every other agent with United can add it at the gate, this man couldn’t be bothered.

Short flight - no food understandable. Flight was delayed for over an hour. Overall, it was good.

Boarding always seems a bit chaotic. Seat spacing could leave more for leg room.

First class felt like economy, seats were horrible, food was horrible, staff inattentive

Terrible. Still have not received the refund from them. They sent it to some account that I don't even know. Spoke with costumer service and they are unable to help.

I didn’t like it at all. I miss my second flight because of the delay on Allegiant Air now I m stuck in MCO.

Good, but a bit late on take off after loading. Don't like charging for carry ons!

First time flying with them and will definitely fly again in the future. Crew was so nice and friendly, fought was seamless. They are simple planes, no entertainment, but it’s fine for a short flight or if you have personal devices Rates are competitive, and they did so well with keeping the flight on time after a tropical storm, where other airlines had delays and cancellations.

They boarded passengers that sat in the back of the plane first, making boarding very efficient.

I didn't even take this flight. My plans changed and I couldn't get ahold of customer service and the website kept breaking down during the attempt to change the flight. I wound up taking another airline entirely and eating the cost.

The worst flying experience ever 3 delays. No accommodations. Had to deboard the plane after being delayed.

Posted a 20minute delay but didn’t delay at all. Caused boarding issues and confusion. Also, didn’t release baggage. Took over an hour and 20 minutes to get luggage.

Flight was good, boarding was a breeze, flight attendants were friendly and professional. There was a medical issue with another passenger and the crew handled it in a calm and professional way.

The net issue I had was with the gate agent. We had added a carryon to our boarding pass when we checked bags. When I got to the boarding gate the agent was rude asking why I had a backpack - I said I added it - even had an orange tag on it. She ripped my tag off and swung her monitor around to show me how she was right- saying it isn’t wasn’t listed - only a checked bag. I explained again that I wasn’t sure what the issue was but I wouldn’t have an orange tag if I hadn’t added it. Then she finally checked my husband’s boarding pass and found that the agent at checkin had added my carryon to his boarding pass instead of mine. She sent me on my way without my orange tag. Was a bit embarrassing for me the tone she used with me assuming I was trying to get away with something.

We boarded after several delays due to mechanical failure and a gate change. The seat cushion in the exit row was very compressed and offered no cushion, making the four-hour journey reasonably uncomfortable. The WiFi worked for a few people, but for most, it did not, and you cannot get entertainment unless you can connect—American Airlines flights do not have seatback screens, and you must use your mobile phone.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

After several delays and being rebooked onto a layer flight, I had to speak to three AA agents for baggage claim to get an attendant. All were in foul mode and reluctant to assist or offer any assistance.

Only thing that I liked it that I got to my destination safely, otherwise American Airlines stinks.

Improvements in communication and empathy are absolutely necessary for American Airlines staff (top down). It’s like they are numb to the needs of their customers.

You were more on time than United. I'm so over united delays.

Good communication at the gate and very nice crew in the flight

Timely boarding process, made up for lost time even after a lengthy wait for de-icing

My seat was wonky...hard and not much padding. I sat next to the Jumpseat for the flight attendant. Thoroughly enjoyed not have a third seat in that row! Flight attendants were amazing. I couldn't answer the "food quality" question as there is no food served on my short flight. I commend the pilot as I know it was super gusty when we landed. Thanks

Seating was horrible. Small seats. Access to flight information and extras very iser unfriendly. Kept losing internet after paying for it. Staff in madison was as unprofessional and unhelpful.

Better service, stop treating people like cattle, have REAL FOOD for the price of the ticket. YOU ARE IN BANKRUPTCY, WAKE UP!!! ... DO BETTER, PLAN BETTER, GIVE COMFORT AND CARE TO PASSENGERS ... EARN RESPECT AND ADMIRATION, YOU'LL BE REWARDED BY THE PUBLIC.

It was good. All snacks/ drinks must be paid during flight. Bring cash with you.

The plane had to wait an hour before docking, then another 1.5 hrs to get our luggage. Bad experience.

The ticket agent wouldn't check our bags, eventhough the flight was delayed and wouldn't board for another hour. The gate agents were only mildly better than the ticket agent. They also had a terrible attitude and work ethics.

The check-in process at Spirit was horrible. There was no one directing the hundreds of people trying to check-in and drop bags at Spirit. We got in multiple lines and were later told it wasn’t a line. The check-in process needs to be improved. The flight and crew were great.

The flight itself was good. Definitely a no frills flight. Pay for what on flight, drink, snack. Flight was delayed to start with, then after boarding and doors closed, still sat there for another 40mins before backing out for departure. When heading back home, there were 2 delays that put me back home 2hrs later than expected. Both times I had people waiting.

we are al people and we go through stuff so my scale is only how i felt, I understand we are all humans, i would definitely ride with soirit again, people in orlando are very helpful which makes it all the better .

I couldn't understand the crew when they announced it was a new plane and there was therefore no wifi, huh? Seriously lame for 2025!

My experience was very nice. However, my Spirit flight 409 from Las Vegas to Tampa… the gate Associate Tissa was extremely unprofessional and boarder line rude. While in line I found out that my Uncle died… in that moment Tisza asked if I would help in car of an emergency as I paid for an exit row seat. I stayed “I will”… Tissa didn’t hear then implied that I didn’t understand English, yelled that I needed to speak up and other things. Associates like that will cause Spirit airlines to lose customers.

We got to fly on the new airplane. Much better as it’s roomier and cleaner than before. Most Importantly it’s much more comfortable. I still can’t move the seat back but the extra space made up for it. I didn’t taste the food or drinks because they charge for everything so I didn’t bother. I didn’t experience the entertainment because I downloaded my own movies on my phone. The crew was great. The flight itself was smooth . No complaints.

Book cheap flights from Indianapolis to South Carolina

Recent round-trip flight deals

 
These are the cheapest round-trip flights from Indianapolis to South Carolina found on KAYAK in the last 72 hours.
3/8Sat
1 stopFrontier
14h 18mIND-CLT
3/10Mon
1 stopFrontier
21h 53mCLT-IND
$124
1/27Mon
1 stopSpirit Airlines
14h 20mIND-CLT
1/29Wed
1 stopSpirit Airlines
9h 01mCLT-IND
$138
5/30Fri
nonstopAllegiant Air
1h 57mIND-CHS
6/2Mon
nonstopAllegiant Air
1h 52mCHS-IND
$170
3/14Fri
nonstopAllegiant Air
1h 48mIND-SAV
3/17Mon
nonstopAllegiant Air
1h 51mSAV-IND
$183
1/29Wed
1 stopDelta
6h 32mIND-CAE
2/1Sat
1 stopDelta
4h 32mCAE-IND
$229
1/24Fri
1 stopDelta
3h 55mIND-CAE
1/30Thu
1 stopDelta
5h 20mCAE-IND
$234
2/1Sat
2 stopsUnited Airlines
8h 14mIND-CAE
2/7Fri
2 stopsUnited Airlines
8h 25mCAE-IND
$251
2/1Sat
2 stopsUnited Airlines
10h 19mIND-CAE
2/7Fri
2 stopsUnited Airlines
8h 25mCAE-IND
$252
3/26Wed
1 stopAmerican Airlines
4h 19mIND-HHH
4/2Wed
1 stopAmerican Airlines
4h 03mHHH-IND
$259
1/24Fri
1 stopAmerican Airlines
5h 20mIND-HHH
1/28Tue
1 stopAmerican Airlines
6h 02mHHH-IND
$264

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Recent one-way flight deals

 
Only flying one-way? Below are some of the best one-way flight deals from Indianapolis to South Carolina found on KAYAK in the last 72 hours.
3/10Mon
1 stopFrontier
6h 22mIND-CLT
$55
1/23Thu
1 stopFrontier
19h 23mIND-CLT
$65
2/11Tue
2 stopsSpirit Airlines
15h 04mIND-MYR
$69
2/25Tue
2 stopsSpirit Airlines
18h 33mIND-CLT
$70
5/24Sat
nonstopAllegiant Air
1h 43mIND-MYR
$81
3/24Mon
nonstopAllegiant Air
1h 48mIND-SAV
$112
2/11Tue
1 stopDelta
4h 32mIND-GSP
$122
1/25Sat
1 stopAmerican Airlines
6h 06mIND-GSP
$124
2/10Mon
1 stopDelta
4h 31mIND-GSP
$129
2/11Tue
1 stopAmerican Airlines
4h 57mIND-CHS
$137

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Last minute flights from Indianapolis to South Carolina

Last minute flight, train and bus deals

 
These last-minute flight deals are the cheapest flights found on KAYAK in the last 72 hours for flights from Indianapolis to South Carolina that are departing in the next 10 days.
1/14Tue
multi-stopSpirit Airlines
14h 20mIND-CLT
1/15Wed
multi-stopSpirit Airlines
15h 14mCLT-IND
$188
1/12Sun
multi-stopSpirit Airlines
9h 53mIND-MYR
1/14Tue
multi-stopSpirit Airlines
6h 04mMYR-IND
$241
1/11Sat
nonstopAmerican Airlines
1h 44mIND-CLT
1/14Tue
nonstopAmerican Airlines
1h 46mCLT-IND
$451
1/11Sat
multi-stopAmerican Airlines
6h 54mIND-CLT
1/14Tue
nonstopAmerican Airlines
1h 55mCLT-IND
$461
1/11Sat
multi-stopDelta
4h 16mIND-CLT
1/15Wed
multi-stopDelta
3h 49mCLT-IND
$471
1/11Sat
multi-stopUnited Airlines
6h 54mIND-CLT
1/14Tue
multi-stopUnited Airlines
8h 15mCLT-IND
$476
1/11Sat
multi-stopUnited Airlines
9h 45mIND-CLT
1/14Tue
multi-stopUnited Airlines
7h 13mCLT-IND
$481
1/12Sun
multi-stopSouthwest
10h 00mIND-CLT
1/14Tue
multi-stopSouthwest
8h 30mCLT-IND
$491
1/10Fri
multi-stopDelta
5h 27mIND-CLT
1/15Wed
multi-stopDelta
5h 57mCLT-IND
$498
1/12Sun
multi-stopSouthwest
9h 40mIND-SAV
1/19Sun
multi-stopSouthwest
4h 45mSAV-IND
$612

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Everything you need to know for your flight from Indianapolis to South Carolina

Information on your arrival and departure airports

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