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If you are looking for a hotel close to Southern Illinois Center, you should consider staying at Fairgrounds Inn, Francies Inn and Super 8 by Wyndham Du Quoin, as they are the most recommended by KAYAK users.
After you launch a hotel search on KAYAK, you can refine your research by neighborhood, which allows you to pick the central Du Quoin districts. You can also do a search using the city map to choose a specific location, like Du Quoin city center.
Take a look at our extensive hotel map to find the best hotels near you.