Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Bissau (95% of total searches to Guinea-Bissau). The next most popular destinations are Rubane Island (2%) and Mansôa (2%). Searches for hotels in Bubaque (1%) are also popular.
Based on KAYAK hotel searches, the most popular region to stay in Guinea-Bissau is Bissau. Bolama and Oio are also very popular.